Acetyl Hexapeptide-8: The innovative solution for youthful skin

Acetyl Hexapeptide 8, also known as Argireline, has established itself as a breakthrough active ingredient in the cosmetics industry in recent years. With its versatile application possibilities and scientifically proven effects, it is a must-have in anti-aging products. In this blog post, we take a look at the properties, effects, benefits and challenges of this innovative active ingredient and provide insights into possible product ideas.

Physicochemical properties of acetyl hexapeptide-8

Acetyl hexapeptide-8 is a white, flaky crystalline powder with a purity of ≥98%. It is water-soluble and has a recommended use concentration of 0.000001 to 2%. The active ingredient mimics the N-terminal end of the protein SNAP-25 and thereby influences the formation of the SNARE complex, which inhibits the release of neurotransmitters and thus reduces muscle contraction.

A brief excursion to Snap-25: How does SNAP-25 work?

SNAP-25 (Synaptosomal-Associated Protein 25) is a protein that plays an important role in communication between nerve cells. It belongs to the family of SNARE proteins, which are responsible for the fusion of cell membranes – a process that is necessary for the release of neurotransmitters.

SNAP-25 is part of the SNARE complex, which is necessary for the fusion of vesicles (small bubbles containing neurotransmitters) with the cell membrane.

As a result, messenger substances (neurotransmitters) are released into the synaptic cleft and enable the transmission of nerve signals.

Cooperation with other proteins:

SNAP-25 works with syntaxin and synaptobrevin (VAMP-2) to enable vesicle fusion.

These proteins form a kind of molecular “zipper” that pulls the membranes together and triggers fusion.

Effect of Botox (botulinum toxin):

Botulinum toxin cleaves SNAP-25, thus preventing the release of neurotransmitters such as acetylcholine.

This prevents muscles from contracting, causing temporary paralysis – an effect that is used in aesthetic medicine to reduce wrinkles.

Why is SNAP-25 important?

It is important for nerve function and muscle control.
It plays a role in learning and memory processes because it influences signal transmission in the brain.

Mutations or malfunctions of SNAP-25 are associated with neurological disorders such as epilepsy or schizophrenia.

In short, SNAP-25 is a key protein for nerve signaling, and Botox uses its blockade to inhibit muscle movement.

Summary of chemical data Acetyl Hexapeptide 8

INCI name: Acetyl Hexapeptide-8

CAS number: 616204-22-9

Molecular weight: approx. 888.99 g/mol

Appearance: white powder or crystals

Solubility: water-soluble

Recommended concentration: 0.01 % – 2 %; power products up to 20%

pH range: stable between 4.0 and 7.0

Efficacy results and optimal concentration

Acetyl Hexapeptide 8 shows impressive results in reducing wrinkles. Studies on 31 subjects aged 35 to 60 years who applied an emulsion with 0.2% Acetyl Hexapeptide-8 twice daily showed significant improvements in wrinkle depth and number after four weeks.

The recommended concentration for maximum efficacy is 0.05–0.2%, although noticeable results can be seen at lower dosages.

Advantages Acetyl Hexapeptide 8

Anti-aging effect: Acetyl Hexapeptide 8 reduces dynamic wrinkles, which are caused by repeated muscle contractions, giving the skin a smooth appearance.

Safety: The active ingredient is gentle on the skin and does not cause side effects such as rigid facial expressions often associated with more invasive procedures.

Wide applicability: The active ingredient is suitable for various product formats, including gels, creams, serums and emulsions.

Non-invasive: Acetyl Hexapeptide-8 offers a painless alternative to Botox injections, ideal for people who don’t want invasive procedures.

Disadvantages of Acetyl Hexapeptide 8

Sensitivity to concentration: Using too high a dosage can reduce effectiveness or lead to unwanted results.

Slow results for deeper wrinkles: Although the active ingredient reduces dynamic wrinkles, it may take longer for it to show visible results for deeper wrinkles.

Cost: Highly pure peptides like Acetyl Hexapeptide-8 can be costly to produce, which affects the final price of products.

Ideas for using cosmetic products

Thanks to its versatility and efficacy, Acetyl Hexapeptide-8 is ideal for the following product categories:

Anti-aging serums: With high concentrations of peptides for targeted wrinkle reduction.

Day and night creams: Combined with moisturizers for smooth, hydrated skin.

Eye creams: To reduce crow’s feet and fine lines around the eyes.

Face masks: For intensive treatment of tired or stressed skin.

Primers: Cosmetic formulations that smooth the skin and serve as a make-up base.

We like to use the following active ingredients based on acetyl hexapeptide-8:

Summary

Acetyl Hexapeptide 8 is a true game changer in the cosmetics industry. It offers an effective, safe and non-invasive solution for reducing wrinkles and promoting youthful skin. Although the active ingredient comes with costs and specific application requirements, its advantages far outweigh these.

If you are interested in developing innovative products with Acetyl Hexapeptide-8 for your brand, Cosmacon GmbH offers customized solutions. With cutting-edge technology and scientific expertise, we can develop unique products that will delight your customers.

Literature:

Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide–8 and Epidermal Growth Factor on Korean Skin.

An JH, Lee HJ, Yoon MS, Kim DH.Ann Dermatol. 2019 Jun;31(3):263-271.

Polydioxanone Bioactive Sutures-Acetyl Hexapeptide–8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization.

Velazco de Maldonado GJ, Suárez-Vega DV, Miller-Kobisher B, García-Guevara VJ.J Cutan Aesthet Surg. 2023 Oct-Dec;16(4):325-334.

Skin scars and wrinkles temporary camouflage in dermatology and oncoesthetics: focus on acetyl hexapeptide–8.

Palmieri B, Noviello A, Corazzari V, Garelli A, Vadala M.Clin Ter. 2020 Nov-Dec;171(6):e539-e548.