Argireline Peptide – The classic anti-aging active ingredient
Argireline Peptide (trademark of our partner Lubrizol), also known under the INCI name Acetyl Hexapeptide-8, is a groundbreaking active ingredient in the skin care industry. This article highlights the chemical properties, mode of action, advantages, disadvantages and possible uses of this promising peptide.
What is Argireline Peptide?
Argireline is a synthetic peptide consisting of six amino acids. It is derived from the protein SNAP-25 and belongs to the neurotransmitter-inhibiting peptides. Due to its specific structure, it acts specifically on muscle contraction and reduces expression wrinkles without completely paralyzing the skin or muscles.
Physico-chemical data on Argireline Peptide:
CAS number: 616204-22-9
Purity: ≥98%
Appearance: White crystalline powder
Solubility: Soluble in water
Recommended use concentration: 0.01% to 2%
INCI name: Acetyl Hexapeptide-8
The effect of Argireline Peptide
Argireline mimics the N-terminal end of the SNAP-25 protein and competes with the natural protein for the binding site in the SNARE complex. This mechanism prevents the effective release of neurotransmitters, which in turn inhibits muscle contraction. This can reduce expression wrinkles, especially in areas such as the forehead and eye area.
A clinical study with a 0.2% Argireline peptide solution showed impressive results. After four weeks of twice-daily application, wrinkle depth and number were significantly reduced:
Active concentration: 0.2%
Result: Up to 30% reduction in wrinkle depth in clinical studies.
Advantages of Argireline Peptide
Gentle alternative to Botox: unlike injectable botulinum toxins, Argireline is mild and does not carry any invasive risks.
Anti-ageing effect: it reduces expression lines and prevents them from forming.
Safe and well tolerated: Argireline is also suitable for sensitive skin types and has hardly any side effects.
Wide range of applications: It is water-soluble and can be used in various cosmetic formulations such as serums, creams and gels.
Disadvantages of Argireline Peptide
Limited effectiveness for deep wrinkles: Argireline may only have a limited effect on very pronounced wrinkles.
Short-term effects: The effect of Argireline requires continuous use because it is reversible.
Combination required: To achieve optimal results, a combination with other active ingredients such as hyaluronic acid is often recommended.
We have outlined a few innovative product ideas below
Acetyl Hexapeptide-8 (Argireline peptide) is the classic peptide in the cosmetics industry, valued for its wrinkle-reducing properties. It works by reducing muscle contractions, similar to Botox, but without invasive procedures. Here are some innovative product ideas with Acetyl Hexapeptide-8:
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Anti-aging face serum with an immediate effect
Formulation:
Acetyl Hexapeptide-8 (2-5%) to reduce expression lines
Hyaluronic acid (low & high molecular weight) for intense hydration
Niacinamide (vitamin B3) to improve skin elasticity
Caffeine to reduce swelling
Advantage:
Light, fast-absorbing texture
Immediately and sustainably reduces fine lines
Perfect for mature skin or as an anti-stress serum for busy people
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Lifting & Smoothing Eye Cream
Formulation:
Acetyl Hexapeptide-8 (3%) for smoothing crow’s feet
Matrixyl 3000 for stimulating collagen production
Caffeine for reducing dark circles
Vitamin C (stable form, e.g. ascorbyl glucoside) for brightening
Advantage:
Reduces dark circles and puffiness
Smooths fine lines around the eye area
Ideal for tired eyes caused by stress or working at a computer screen
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“Botox alternative” face mask
Formulation:
Acetyl Hexapeptide-8 (5%) for immediate lifting
Kaolin or pink clay for a cleansing effect
Panthenol to sooth the skin
Aloe vera gel for intensive moisture
Advantage:
Immediately tightens the skin
Detoxifies and soothes
Perfect as a weekly intensive treatment
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Wrinkle-Reducing Lip Balm
Formulation:
Acetyl Hexapeptide-8 (2%) to reduce vertical lip wrinkles
Hyaluronic acid for volume and moisture
Shea butter and jojoba oil for supple lips
Vitamin E as an antioxidant
Benefit:
Reduces fine lip wrinkles (smoker’s wrinkles)
Adds volume without injection
Perfect as a base for lipstick
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Lifting Make-up Primer
Formulation:
Acetyl Hexapeptide-8 (3%) for wrinkle reduction
Silk Proteins for a silky texture
Niacinamide for skin smoothing
White Tea extract as an antioxidant
Advantage:
Smooths the skin and perfectly prepares it for make-up
Prolongs the durability of make-up
Acts as a daily anti-aging product
Summary
Argireline is an innovative active ingredient with promising anti-aging properties. By inhibiting muscle contraction, it effectively and gently reduces expression lines. Its versatility and tolerability make it a preferred ingredient in the modern cosmetics industry.
Cosmacon GmbH is happy to support you in the development of innovative cosmetic products based on Argireline and other highly effective active ingredients. Together, we can take your brand to the next level. Please get in touch and we will be happy to provide you with comprehensive advice.
Literature:
Velazco de Maldonado GJ, Suárez-Vega DV, Miller-Kobisher B, García-Guevara VJ.J Cutan Aesthet Surg. 2023 Oct-Dec;16(4):325-334.