Dipeptide Diaminobutyroyl Benzylamide Diacetate – the snake venom peptide

Dipeptide Diaminobutyroyl Benzylamide Diacetate (DDBD) is a popular active ingredient in the cosmetics industry, especially in anti-aging products. This synthetic active ingredient mimics the effect of Waglerin-1, a peptide found in snake venom, and is often referred to as a “gentle Botox replacement”. Due to its ability to relax muscle contractions, it is a revolutionary ingredient for smoothing wrinkles and improving skin texture. But what exactly makes this active ingredient so special, and what are its properties that make it so attractive for skin care?

Properties and chemical-physical data

INCI name: Dipeptide Diaminobutyroyl Benzylamide Diacetate

CAS number: 823202-99-9

Molecular weight: approx. 503.6 g/mol

Molecular formula: C24H36N6O6

Appearance: white to light cream-colored powder

Solubility: water-soluble

Recommended concentration: 0.005–0.5%

Effect: muscle relaxant, anti-wrinkle, skin-tightening, antioxidant

Forms of application: creams, serums, gels, emulsions

Production and mode of action

Dipeptide Diaminobutyroyl Benzylamide Diacetate is synthesized using biotechnology and belongs to the group of neuro-inhibitory peptides. It works by blocking the interaction of acetylcholine with the muscle receptors (nAChRs), which results in a reversible relaxation of the muscles. This can reduce expression lines without affecting natural facial expressions.

Efficacy and recommended concentrations

Studies show that products with a concentration of around 0.2% Dipeptide Diaminobutyroyl Benzylamide Diacetate produce visible improvements in skin structure after four weeks of use. In clinical tests with 36 participants (35–60 years), a significant reduction in wrinkle depth, volume and number was observed.

Immediate effect: a reduction in wrinkle depth was observed after just 15 minutes.

Long-term effect: with continuous use over four weeks, wrinkle depth was reduced by up to 25%.

Advantages of the active ingredient Dipeptide Diaminobutyroyl Benzylamide Diacetate

Effective wrinkle reduction: the targeted relaxation of facial muscles inhibits the formation of dynamic wrinkles.

Non-invasive: in contrast to Botox, the active ingredient does not require any injections.

Skin-friendly: suitable for sensitive skin, as it does not cause any permanent changes to muscles or nerves.

Fast-acting: initial results are often visible after just a few applications.

Combinable: can be combined with other anti-ageing active ingredients such as hyaluronic acid and vitamin C.

Disadvantages and limitations

Cost: products with this active ingredient are often more expensive than conventional cosmetics.

Long-term effect: when the active ingredient is discontinued, the effect diminishes, which is why regular use is necessary.

Active ingredient stability: sensitive to pH changes, which requires precise formulation.

Ideas for using cosmetic products with Dipeptide Diaminobutyroyl Benzylamide Diacetate

The versatility of Dipeptide Diaminobutyroyl Benzylamide Diacetate makes it an ideal ingredient for various product formulas:

Anti-aging serums: highly concentrated serums for targeted wrinkle treatment.

Day and night creams: combine with moisturizers such as hyaluronic acid for comprehensive skin care.

Eye contour care: specialized formulas for treating crow’s feet and fine lines around the eyes.

Firming face masks: intensive care for an instantly visible lifting effect.

BB or CC creams: complementing decorative cosmetics with anti-aging effects.

We like to work with these DDBD-based active ingredients:

Summary of Dipeptide Diaminobutyroyl Benzylamide Diacetate

Dipeptide Diaminobutyroyl Benzylamide Diacetate is an innovative active ingredient that is revolutionizing modern anti-aging cosmetics. With its ability to reduce wrinkles and firm skin, it offers a gentle and effective alternative to invasive methods. Products with this active ingredient are particularly appealing to customers who want visible results without risks and side effects.

Cosmacon GmbH is ready to help you develop customized cosmetic products with this unique active ingredient. Take advantage of our expertise to strengthen your brand with innovative solutions!

Literature:

INDIVIDUAL ARTICLE: Real-World Clinical Experience With a Neuro-Peptide Serum in Combination With Botulinum Toxin Type-A Injections. Lupin M, Bjerring P, Andriessen A, Chantrey J, Fabi SG, Liew S, McDonald C, Xiaolei Q, White S. J Drugs Dermatol. 2024 Nov 1;23(11):43661s3-43661s14.