Mechanotransduction
Mechanotransduction is a process that takes place in our body in which physical signals are converted into molecular intracellular reactions. These in turn lead to positive structural changes. In our body, mechanotransduction is mainly responsible for controlling cell functions. Even if we are not consciously aware of it, it takes place all the time. Probably the best known and simplest example is walking or running. Mechanical stimuli are exerted on our bones with every step we take. The bone cells then convert these stimuli into a biochemical reaction: As a result, more bone substance is formed and the bones become stronger and denser. It is not without reason that exercise is the best way to prevent osteoporosis. However, mechanical stimuli are not only important for keeping our bones healthy. The tissue, muscles, veins and skin also need appropriate stimulation. However, our normal everyday exercise is not always sufficient for this. Not even the long walk at the weekend, the laps in the swimming pool or the training session at the gym. If we want to combat cellulite, for example, we need to induce additional artificial mechanotransduction, as this does not occur naturally in fat cells.
Targeted mechanotransduction
Skin cell renewal can also be effectively stimulated by mechanical stimulation. There are already special active ingredients that specifically activate the proteins responsible for cell renewal so that the skin renewal process is stimulated. A study with test subjects between the ages of 35 and 65 has already confirmed their effectiveness. It showed that the active ingredient was able to increase the skin’s cell renewal rate by almost 47 percent compared to the control group after just eight days. Artificially induced mechanotransduction is therefore a real revolution in the cosmetics industry. When we consider that our skin is not only our most important beauty feature, but also serves as a kind of protective shield against environmental pollution, UV radiation, stress, pathogens and other influences, the significance of artificial mechanotransduction takes on an immense dimension. After all, the epidermis can only fulfill its tasks optimally if it renews itself regularly through cell proliferation and cell differentiation. If the natural mechanotransduction is gently but specifically supported, the skin not only appears fresher, younger and smoother, it can also perform its protective function against harmful influences much better. The tiny particles of the innovative active ingredient are only 100 to 200 micrometers in size and produce a white powder. They are incorporated into the formulation at the very end at an application concentration of 3.5 percent.
EasyWay profile
INCI: Cellulose Acetate
Description: white powder, particle size 100 to 200 micrometers
Preservation: none
Application concentration: 3.5 percent is recommended.
Area of application: as an artificially produced mechanotransduction to improve the skin renewal rate
The principle of mechanotransduction in cosmetics
The majority of human tissue is dependent on mechanical stress and therefore on mechanotransduction. This is the only way to maintain a healthy condition. If the stimulation is missing, the tissue becomes weaker and breaks down. This is why, for example, patients are mobilized as quickly as possible after an injury to muscles and ligaments or after an artificial joint replacement. The principle of mechanotransduction can also be used in cosmetics, for example to accelerate cell renewal in the skin. A newly developed active ingredient is able to do just that. This has not only been proven in an in-vitro study, but also in an efficacy study with 20 test subjects.
We are convinced that this active principle also works with other particulate substances and therefore often use tapioca starch, rice starch, ground carnauba beads etc. to take our formulations to a new level for our customers.
We will be happy to answer any questions you may have on this topic.
Literature:
Iheanacho F, Vellipuram AR.2023 Sep 4. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–.PMID: 31082112
Grundlagen der zellulären Mechanotransduktion
verfasst von: S. Tietze, A. Hofmann, S. Wolk, C. Reeps
Erschienen in: Gefässchirurgie | Ausgabe 4/2020